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Inward Rotating Spiral Waves in Glycolysis

Straube, R; Vermeer, S; Nicola, Ernesto M.; Mair T.
Biophysical Journal 99, L4-L6 (2010)

We report on the first observation of inward rotating spiral waves (antispirals) in a biochemical reaction-diffusion system. Experiments are performed with extracts from yeast cells in an open spatial reactor. By increasing the protein concen- tration of the extract we observe a transition from outward to inward propagating waves of glycolytic activity. Numerical simulations with an allosteric model for the phosphofructokinase can reproduce these inward propagating waves over a wide range of parameters if the octameric structure of yeast phosphofructokinase is taken into account. Link: http://www.cell.com/biophysj/abstract/S0006-3495(10)00483-2